Endocrine Abstracts

Aim: The investigation of female androgen status in our laboratory is measured as a profile. Androstenedione, testosterone and DHEAS are analysed by liquid chromatography–tandem mass spectrometry. SHBG is analysed by immunoassay, and all results are reported simultaneously. The main aim was to investigate the management of patients who have a raised DHEAS level.Method: Ethical approval was granted for this study. Females with DHEAS levels >6.9 n...

Background: Accurate measurement of serum cortisol is essential in the investigation of the HPA axis. It has been documented that routine immunoassays are liable to both under- and over-recovery leading to inaccurate results and subsequent inappropriate investigations. This study seeks to provide an up-to-date assessment of the accuracy of the major immunoassay platforms and compares results to a liquid chromatography–tandem mass spectrometry (LC–MS/MS) candidate ref...